Primrose Bio is heading to the 14th International mRNA Health Conference, November 17-19, 2026 at the Westin Copley Place, Boston, MA.
Patrik Engström, Principal Scientist, will be giving a talk on Choosing the Right Enzyme for RNA Manufacturing and Therapeutics. Jasmina Radoicic, PhD, Senior Scientist, will be presenting a scientific poster on Engineered RNA Polymerases for Improved Yield, Integrity, Capping, and dsRNA Control in IVT. Andrew Burch, Chief Executive Officer, will also be in attendance. Stop by our exhibit and connect with Jennifer Wittbold, Associate Director, Product & BD, to learn more about how Prima RNApols® are advancing mRNA manufacturing.
Engineered RNA Polymerases for Improved Yield, Integrity, Capping, and dsRNA Control in IVT
RNA therapeutics are rapidly expanding across a wide range of applications, including oncology, infectious diseases, rare diseases, cardiovascular disease, and autoimmune diseases. Central to RNA manufacturing is in vitro transcription (IVT), a method that uses RNA polymerases to synthesize RNA. To reduce manufacturing costs and unwanted immunostimulatory products, Primrose Bio developed Prima RNApols®, a portfolio of engineered RNA polymerases. These RNA polymerases are designed to integrate into industry RNA workflows by consistently delivering on key performance indicators: yield, integrity, capping efficiency, and ultra-low double-stranded RNA (dsRNA), increasing translation in human cells.
To develop the high-performance Prima RNApols®, Primrose Bio built an enzyme evolution platform based on ultra-high-throughput screens and protein-engineering approaches. The wealth of data generated by the evolution platform puts Primrose Bio in a favorable position to address future manufacturing challenges through AI-based protein engineering and tailored enzyme evolution.
Primrose Bio’s Prima RNApols® are advancing mRNA manufacturing, offering a stronger alternative to legacy enzymes, improving the scalability, quality, and customization of mRNA therapeutics for the future of medicine.
