Insights / Resource Center

Resources

Events

Scientific Posters

Case Studies

Pfenex

Recombinant Erwinia Asparaginase Production

Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. Lymphoblastic lymphoma (LBL) is a rare, fast-growing, aggressive subtype of non-Hodgkin’s lymphoma most often seen in teenagers and young adults.

Pfenex

Production of disulfide-rich cow knob domain antibodies: picobodies™

About 10% of cow antibodies have exceptionally long heavy chain CDR3 regions, including a stalk and knob region.

Pfenex

Multimeric vhh nanobody expression

VHH single domain antibodies readily express in the Pfenex Expression Technology®. Expression and enrichment of a variety of VHH specificities facilitated early drug development.

Pfenex

Fab antibody fragment titer improvement

A partner was developing a Fab fragment to quickly neutralize a therapeutic substrate. Their E. coli platform generated low Fab titer and meaningful supply was needed for clinical development.
Pelicrm197

Anti-IL-4 Conjugate Vaccine Prepared with PeliCRM197 is More Immunogenic than KLH Analog

Anti-interleukin 4 (IL-4) conjugate vaccines consist of IL-4 chemically coupled to a carrier protein. Immunizations with these vaccines, in combination with an adjuvant, elicit the production of polyclonal anti-IL-4 neutralizing antibodies in mice.
Pelicrm197

Comparable Immunogenicity Observed in Peptides Coupled to PeliCRM197 and KLH in a Murine Model

In this case study, 3 peptides (peptides #5, #6, and #7) directed to one therapeutic target were conjugated to either CRM197 (a non-toxic diphtheria toxin mutant) produced with Pfenex Expression Technology® or to KLH (keyhole limpet hemocyanin).

Success Stories

Manufacturing of RYLAZE utilizes Pfenex Expression Technology

Hear from the senior director for the biologics development team at Jazz Pharmaceuticals about the RYLAZE manufacturing process.

#

Return to Insights