SPEED, SCALABILITY AND
PROVEN COMMERCIAL SUCCESS
Your Protein. A GMP-Ready
Manufacturing Process.
From sequence to a scalable, manufacturing-ready process.
Whether you are evaluating a new molecule, improving
expression, scaling a process, or preparing for
manufacturing — we help you determine the right path
forward.
I need to express a new protein
Starting from sequence with no established production strategy.
..
My yields are too low or inconsistent
Expression works, but not at the level or quality required.
Site specific conjugation
I’m struggling to make a protein incorporating a ncAA coding sequence.
I’m running into downstream or quality issues
Purification challenges, impurities, or product quality constraints.
I need material for studies
Preclinical material, GLP lots, or data to support advancement decisions.
Platform
A high-yield microbial expression platform built on Pseudomonas fluorescens,
engineered specifically for biologics production, not adapted from a laboratory
research tool. Pfenex supports protein expression from early-stage evaluation
through manufacturing-ready process development. We integrate strain engineering, process development, and analytics in one system — so you don’t have to manage multiple handoffs.
Approved vaccines and therapeutics marketed worldwide by leading pharmaceutical companies.
80%
success rate, titer, quality
≤30g/L
Up to 30 g/L titers
6
approved biologics
25+
global tech transfers
200+
lead proteins generated
PATHWAYS
What the Process Looks Like
Rapid Screen
Subset toolbox • pooled ligation
Pooled cloning
HTP 96-well screen
Hit enrichment – expression report
Full HTP SCreen
Full combinatorial screen
Hit selection & characterization
Maximum coverage
2L robustness screen
High cell density • scalable strain selection
Research cell bank
Process development
Material generation
Tech transfer
Analytical capabilities
- Titer & purity assessment
- Mass spec
- HPLC/SEC
- SDS-CGE
- In-process sampling
- Release testing