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Fusion-Enabled Biosimilar Peptide Teriparatide Expression 

Fusion-Enabled Biosimilar Peptide Teriparatide Expression 

by Primrose Bio | Aug 24, 2026 | Case Studies

Challenge Teriparatide, a recombinant PTH (1-34) fragment used in osteoporosis therapy, is a short peptide that can be difficult to express and recover efficiently. The program required building production strains for the 34-mer, evaluating fusion partner designs in a...
Production of disulfide-rich cow knob domain antibodies: Picobodies™ 

Production of disulfide-rich cow knob domain antibodies: Picobodies™ 

by Primrose Bio | Aug 24, 2026 | Case Studies

BACKGROUND About 10% of cow antibodies have exceptionally long heavy chain CDR3 regions, including a stalk and knob region. The knob region of CDR H3 is about 4-6 kDa in size with a highly diverse sequence content and multiple disulfide bonding patterns : these are...
Comparable Immunogenicity Observed in Peptides Coupled to PeliCRM197 and KLH in a Murine Model

Comparable Immunogenicity Observed in Peptides Coupled to PeliCRM197 and KLH in a Murine Model

by Primrose Bio | Sep 10, 2025 | Case Studies

Anti-IL-4 Conjugate Vaccine Prepared with PeliCRM197 is More Immunogenic than KLH Analog

Anti-IL-4 Conjugate Vaccine Prepared with PeliCRM197 is More Immunogenic than KLH Analog

by Primrose Bio | Sep 9, 2025 | Case Studies

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