Streamlining Discovery and Development for ncAA Incorporation and Extracellular Protein Production

Presented at PEGS Boston 2026 by Primrose Bio. Streamlined product discovery and development workflows are critical to facilitate efficient decision making and candidate advancement. Improvements in extracellular (EC) localization and ncAA incorporation within the Pfenex platform can accelerate discovery and development timelines. Engineered host strains show EC production of a wide range of proteins, enabling streamlined recovery and analysis. Further, high fidelity, high titer production of target proteins with 100% ncAA incorporation has been established, with titers up to 15g/L in fermentation.