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Primrose Bio's Resource Center

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Pfast™ Protein Expression

A Rapid, Robust Solution for Accelerating Biotherapeutic Screening

Achieving High Quality Efficient mRNA Synthesis

For Streamlined and Cost-Effective Manufacturing

Scientific Posters

Case Studies

Pfenex

Recombinant Erwinia Asparaginase Production

Acute lymphoblastic leukemia (ALL) is the most common type of cancer in children. Lymphoblastic lymphoma (LBL) is a rare, fast-growing, aggressive subtype of non-Hodgkin’s lymphoma most often seen in teenagers and young adults.

Pfenex

Production of disulfide-rich cow knob domain antibodies: picobodies™

About 10% of cow antibodies have exceptionally long heavy chain CDR3 regions, including a stalk and knob region.

Pfenex

Multimeric vhh nanobody expression

VHH single domain antibodies readily express in the Pfenex Expression Technology®. Expression and enrichment of a variety of VHH specificities facilitated early drug development.

Pfenex

Fab antibody fragment titer improvement

A partner was developing a Fab fragment to quickly neutralize a therapeutic substrate. Their E. coli platform generated low Fab titer and meaningful supply was needed for clinical development.
Pelicrm197

Anti-IL-4 Conjugate Vaccine Prepared with Pfenex CRM197 is More Immunogenic than KLH Analog

Anti-interleukin 4 (IL-4) conjugate vaccines consist of IL-4 chemically coupled to a carrier protein. Immunizations with these vaccines, in combination with an adjuvant, elicit the production of polyclonal anti-IL-4 neutralizing antibodies in mice.
Pelicrm197

Comparable Immunogenicity Observed in Peptides Coupled to Pfenex CRM197 and KLH in a Murine Model

In this case study, 3 peptides (peptides #5, #6, and #7) directed to one therapeutic target were conjugated to either Pfenex’s CRM197 (a non-toxic diphtheria toxin mutant) or to KLH (keyhole limpet hemocyanin).
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