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Improving Scale-up Starts With Expression Strategy
Many recombinant protein programs face critical expression challenges long before manufacturing begins. Poor yield, solubility issues, secretion limitations, and uncertain scalability can consume...
How Polymerase Selection Improves IVT Outcomes
Self-amplifying RNA (saRNA) manufacturing places stringent demands on in vitro transcription (IVT), particularly for long templates where polymerase processivity, transcript integrity, capping...
Streamlining Discovery and Development for ncAA Incorporation and Extracellular Protein Production
Streamlining Discovery and Development Workflows Using Engineered P. fluorescens Strains for ncAA Incorporation and Extracellular Protein Production Diane Retallack, President & COO, Primrose...
Strategies To Reduce mRNA Manufacturing Costs
Manufacturing costs are one of the most pressing challenges facing teams working to scale RNA therapeutic and vaccine pipelines. In vitro transcription, or IVT, relies on several central raw...
Double Stranded RNA Formation And How RNA Polymerase Choice Can Reduce It
Double-stranded RNA is one of those stubborn byproducts that can quietly inflate downstream purification costs and compromise mRNA product quality. In this presentation, Patrik Engström, Principal...
Accelerating Antibody Screening with a Scalable Protein Expression Platform
Diane Retallack, President & COO, Primrose Bio at PepTalk: The Protein Science and Production Week at San Diego, CA P. fluorescens-based Pfenex Expression Technology® transforms protein...
A Rapid, Robust Solution for Accelerating Antibody Screening
A Rapid, Robust Solution for Accelerating Antibody Screening: P. fluorescens-based Pfenex Expression Technology® transforms protein production through combinatorial screening to identify robust...
Pfast™ Protein Expression: A Rapid, Robust Solution for Accelerating Biotherapeutic Screening
P. fluorescens-based Pfenex Expression Technology® (Pfenex) transforms protein production through combinatorial screening to identify robust strains. With 20+ years of development and 6 marketed...
